Trichloroethylene: Johnson et al.'s Response

Postscript : Rejoinder to Johnson et al . (

In their postscript, Johnson et al. (2008) emphasized that models of heuristics and their adaptive use will advance research on risky choice. We agree wholeheartedly. Yet they had two empirical concerns. First, they argued that although only 3 of 28 tests were significant in the opposite direction of what the priority heuristic predicts, one of them, the test for outcome-probability (probabilit...

Response to Johnson and Danhauer

We thank Johnson and Danhauer for pointing out our oversight of calling the ED-NST the CUNY-NST. The nonsense syllable test that we used in the Auriemmo et al (2009) study was indeed the Edgerton-Danhauer Nonsense Syllable Test (ED-NST), which we have referenced correctly throughout the manuscript. We also agree with Johnson and Danhauer on the requisite considerations in administering an open-...

Public Participation: Methods Matter; A Response to Boaz et al.

Trichloroethylene (TCE)

Current evaluation Conclusion from the previous Monograph: Trichloroethylene (TCE) is probably carcinogenic to humans (Group 2A) based on limited evidence in humans for the carcinogenicity of TCE and sufficient evidence in experimental animals for the carcinogenicity of TCE. In making the overall evaluation, the Working Group considered the following evidence: (i) although the hypothesis linkin...

Statistical analysis of Fisher et al. PBPK model of trichloroethylene kinetics.

Two physiologically based pharmacokinetic models for trichloroethylene (TCE) in mice and humans were calibrated with new toxicokinetic data sets. Calibration is an important step in model development, essential to a legitimate use of models for research or regulatory purposes. A Bayesian statistical framework was used to combine prior information about the model parameters with the data likelih...